Clinical Study

THE REJUVENATING WONDERS OF VEGETAL PLACENTA

MF3 Official Site / MF3 VP Softgels AF / Clinical Study

CLINICAL STUDY 1

As an integral part of cell membranes, Phosphatidylcholine is essential for the cellular structural and functional integrity. Extracted from special soy-beans Non-GMO (Non-Genetically Modified Organisms), PPC (polyenylphosphatidyicholine) has been shown to enhance cell membrane function throughout the human body.

In fact in many European countries, PPC is approved for chronic liver disorders . It is also being investigated for the management of hepatitis C.

PPC’s beneficial effect is believed to be based on its unique ability to be incorporated into normal and damaged cell membranes. PPC, is a polyunsaturated phosphatidylcholine that incorporates into the membranes of liver cells as a substitute for saturated phosphatidylcholine. This substitution results in an increase in membrane fluidity and transport activity across the membrane. Similarly, PPC is incorporated into blood lipoproteins, leading to lipid-lowering properties.

PPC lowered LDL by about 15%, triglycerides levels by 32%-and raised HDL by 10% in one clinical trial.

PPC also appears to have high antioxidant properties, which means it may reduce the oxidative stress (cellular changes that generate cell-damaging free radicals) shown to be a contributing factor in the hyper-immune responses and scarring of common hepatic disorders.

VP Softgels contains pure PPC (polyenylphosphatidylcholine)

European pharmaceutical standards. Each 1780 mg VP softgel capsule is well absorbed when taken orally and has no known contraindications, side effects, or interactions with other drugs.

Clinical Reference

Horejsova M, Urban J. The effect of polyene phosphatidyicholine in the treatment of liver steatosis and ultrasound findings–preliminary study. Cas Lek Cesk 1994; 133(12):366-9.

CLINICAL STUDY 2

Polyenylphosphatidylcholine inhibits PDGF-induced proliferation in rat hepatic stellate cells.

A polyunsaturated phospholipid extract from soy beans, Polyenylphosphatidylcholine (PPC), prevents the development of liver cirrhosis in animal models. Its mechanism of action is unknown. Based on the hypothesis that PPC might act by decreasing hepatic stellate cell proliferation, Studies show the effect of PPC and its main components, dilinoleoylphosphatidylcholine (DLPC) and palmitoyllinoleoylphosphatidylcholine (PLPC), on Platelet Derived Growth Factor (PDGF)- induced stellate cell proliferation and intracellular signal transduction. Normal rat hepatic stellate cells in tissue culture were serum starved, and incubated with 10ng/ml PDGF in the absence or presence of phospholipids. Cell proliferation was measured by 3H- incorporation. Mitogen-activated protein kinase (P44MAPK) activation was determined by kinase assay, and AP-i binding by electrophoretic mobility shift assay. PPC (200 ng/ml) significantly inhibited PDGF-induced proliferation (p less than 0.05;ANOVA, n = 3) and antagonized PDGF-induced P44MAPK activation and AP-1 binding. This effect was mimicked by DLPC but not by PLPC. Neither DLPC nor PLPC prevented PDGF receptor activation. We conclude that PPC exerts a previously unrecognized effect on mitogen-induced stellate cell proliferation which may be mediated by DLPC. Inhibition of this cascade represents a potential mechanism for the inhibitory effect of PPC on hepatic fibrogenesis.

Clinical Reference : Biochem Biophys Res Cominun. 1998 Jul 9;248[1]:174-9.

PPC (polyenylphosphatidylcholine) in VP

As an integral part of cell membranes, Phosphatidylcholine is essential for the cellular structural and functional integrity. Extracted from special Non-GMO (Non-Genetically Modified Organisms) soy-beans , PPC (polyenylphosphatidylcholine) has been shown to enhance cell membrane function throughout the human body. PPC also appears to have high antioxidant properties, which means it may reduce the oxidative stress (cellular changes that generate cell-damaging free radicals) shown to be a contributing factor in the hyper-immune responses.

VP Softgels contains pure PPC (polyenylphosphatidylcholine) (European pharmaceutical standards). Each 1780 mg VP softgel capsule is well absorbed when taken orally and has no known contraindications, side effects, or interactions with other drugs.Internal Research Tests were conducted on a group of healthy, female volunteers with age ranging from 40 to 65 years old, exhibiting clear signs of improvement in skin hydration, wrinkle reduction, skin softness, smoothness and firmness.These internal studies results also clearly indicate:

A cellular regeneration of the support matrix (elastin and collagen).
A positive action of our VP on cellular stimulation in the dermis.
Synthesis of reservoir molecules-such as glycosaminoglycans (GAG).

For more related clinical studies, please click here.